Calcium Phosphates as Delivery Systems for Bisphosphonates
نویسندگان
چکیده
Bisphosphonates (BPs) are the most utilized drugs for the treatment of osteoporosis, and are usefully employed also for other pathologies characterized by abnormally high bone resorption, including bone metastases. Due to the great affinity of these drugs for calcium ions, calcium phosphates are ideal delivery systems for local administration of BPs to bone, which is aimed to avoid/limit the undesirable side effects of their prolonged systemic use. Direct synthesis in aqueous medium and chemisorptions from solution are the two main routes proposed to synthesize BP functionalized calcium phosphates. The present review overviews the information acquired through the studies on the interaction between bisphosphonate molecules and calcium phosphates. Moreover, particular attention is addressed to some important recent achievements on the applications of BP functionalized calcium phosphates as biomaterials for bone substitution/repair.
منابع مشابه
Adsorption on apatitic calcium phosphates for drug delivery: interaction with bisphosphonate molecules.
Bisphosphonates (BPs) are well established as an important class of drugs for the treatment and prevention of several bone disorders including osteoporosis. This work investigated the interaction of two bisphosphonates, risedronate and tiludronate, with several apatitic supports, a well-crystallised hydroxyapatite (HA) and nanocrystalline apatites with varying maturation times, chemical composi...
متن کاملBisphosphonate Prodrugs Utilizing Endogenous Carriers
Targeting of therapeutic agents to a specific site, as well as controlling the rate and time of release, has been intensively investigated and established over the last decades. These studies concerning drug delivery systems led to the formulation of several products that can improve the diffusion across the barriers after drug administration. For this purpose, the development of strategies of ...
متن کاملCalcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review.
Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their appli...
متن کاملNanostructured Calcium Phosphates: Preparation and Their Application in Biomedicine
Due to the similar chemical properties to the inorganic component in calcified tissues, synthetic calcium phosphate has been considered as ideal biomaterials with excellent biocompatibility. Nanostructured calcium phosphate materials play an important role in the formation of hard tissues in nature. It is reported that calcium phosphates materials in nano-size can mimic the dimensions of consti...
متن کاملArchive Toulouse Archive
The interaction of calcium phosphates with biological molecules under controlled conditions permits the formulation of meaningful conclusions concerning the driving forces. The uptake and release at the material-solution interface is the result of the various interactions between and within the system components which include the solid surface, the adsorbate, the solvent and other solutes prese...
متن کامل